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Saturday 01 April 2000

Analysis of salbutamol and related impurities by derivative spectrometry.

By: Aboul-Enein HY, Surmeian M.

Arch Pharm (Weinheim) 2000 Apr;333(4):75-8

Ultraviolet derivative spectrometry has been proposed for the analysis of salbutamol and related impurities. The assay of salbutamol aldehyde, 5-formyl-saligenin, and salbutamol ketone was performed in sodium hydroxide 0.1 mol/l solutions, using first and second derivative spectra. The method has been applied for the assay of related impurities of commercial samples of salbutamol sulfate.

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