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Friday 23 March 2001

Solubility prediction of salmeterol xinafoate in water--dioxane mixtures.

By: Jouyban-Gharamaleki A, York P, Hanna M, Clark BJ.

Int J Pharm 2001 Mar 23;216(1-2):33-41

The mole fraction solubility of salmeterol xinafoate was determined in various concentrations of dioxane in aqueous binary mixture. Maximum solubility was observed in 90% v/v dioxane and solubility parameter of the solute was estimated from solubility peak equal to 24.99 MPa(0.5). The predicting capability of four different cosolvency models was also evaluated employing a five data point training set. The solubility data at other cosolvent concentrations were predicted using the trained models, with percentage average errors for 28 drug solubility data sets in water-cosolvent mixtures lying between 12.5 and 15.0%. Further predictive model is proposed for accurate solubility predictions based on a minimum number of experiments. The percentage average error where tested was 10.6%.

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