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Thursday 01 March 2001

[Clinical and epidemiological diagnosis of chronic dust-induced bronchitis]

By: Kosarev VV, Mokina NA, Igumenova IuA.

Gig Sanit 2001 Mar-Apr;(2):43-6

A unified scheme for comprehensive interview of workers of a large metallurgic works who come in contact with occupational noxious agents that cause respiratory organs was used to select 300 workers (199 men and 101 women). They underwent a bicycle exercise test that involved the determination of forced vital capacity (FVC), forced expiratory volume within the first second (FEV1), peak expiratory air flow (PEAF), and the Tiffeneau index. Moreover, the flow/volume ratio was examined on a Flowscreen device (Erich Eger) and a test with a bronchodilator (ventoline, 200 mu/kg) was also made. The authors conducted 64 assays of eosinophilic cationic protein (ECP) and 64 assays of mucinic antigen (MA). Serum ECP and MA levels were measured by immunofluoresence and sandwich-immunofluorescence, respectively. Screening functional indices obtained from the flow/volume and bronchodilator tests are sensitive in both manifestative and latent dust-induced bronchitis so they permit identification of latent and obvious airways obstruction. ECP is a highly reliable diagnostic criterion for the asthmatic form of chronic occupational bronchitis and MA is for its inflammatory form.

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