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Tuesday 23 March 2004

Pilot trial of albuterol in Duchenne and Becker muscular dystrophy.

By: Fowler EG, Graves MC, Wetzel GT, Spencer MJ.

Neurology 2004 Mar 23;62(6):1006-8

The authors conducted a randomized, crossover, double-blind, placebo-controlled pilot study of albuterol in nine boys with dystrophinopathies. Primary outcomes were 1) isometric knee extensor and flexor strength; and 2) manual muscle testing (MMT). Isometric knee extensor strength and MMT scores were significantly higher in patients taking albuterol vs placebo. Therefore, 12-week treatment with extended-release albuterol may increase strength in patients with dystrophinopathies. A larger, double-blind, randomized study is necessary to confirm these results.

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